Monday, January 26, 2009

Resveratrol

Its other name is 3,5,4′-trihydrostilbene. (1) Resveratrol is one the naturally occuring phytoalexin compound. This is found in grapes.

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Resveratrol has been found to increase the life span of yeast and worms. It is thought that it stimulates a deacetylase enzyme namely SIRT1. This enzyme have the ability of regulatin several transcriptional factors and enzymes which are responsible for the nutritional availability. (Mitchell D Knutson et al.)

Therapeutic uses:
It has found practical uses as an anti-cancer agent for breast cancer in both hormone dependent and hormone independent. (Hiroyuki Nakagawa et al.)
It has also been found that it has the ability of protecting against inflammatory arthritis. (N. Elmali et al.)

References:
(1) Encyclopedia of Genetics, Genomics, Proteomics and Informatics, 2008, page 1684

Hiroyuki Nakagawa, Yasuhiko Kiyozuka, Yoshiko Uemura, Hideto Senzaki, Nobuaki Shikata, Koshiro Hioki and Airo Tsubura, 2001, Resveratrol inhibits human breast cancer cell growth and may mitigate the effect of linoleic acid, a potent breast cancer cell stimulator, Journal of Cancer Research and Clinical Oncology, Volume 127, 258-264

Mitchell D Knutson, Christiaan Leeuwenburgh, 2008, Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases, Nutrition reviews, volume 66, 591-596

N. Elmali , O. Baysal , A. Harma , I. Esenkaya and B. Mizrak, 2006, Effects of Resveratrol in Inflammatory Arthritis , Inflammation, volume 30, 1-6

Further reading:
A Cardiologist's Guide to Anti-Aging, Antioxidants & Resveratrol by M.D. Dr. William S. Gruss

Resveratrol in Health and Disease (Oxidative Stress and Disease) by Bharat B. Aggarwal and Shishir Shishodia

Resveratrol and Human Health by Debasis Bagchi

Effects of Naturally Occurring Compounds on HumanCancer Cells: Anticancer Activity of Resveratrol, Piceatannol,Gallic Acid & their Analogs by Philipp Saiko

Natural products:
Source Naturals Resveratrol, Tablets, 60 tablets (Read Nutrition facts)

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